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1st and 10 determines what type of offense you run

Nearly half of all offense plays come on 1st and 10.  So what you do here must match your talent.  The rest of the downs are there to get you back to 1st and 10.  This makes 1st and 10 the most important down in the game.  You need to stress your Offenses strength by going with your best players on this down.
For more information see this article from - First down means everything